The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle
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RIS BIB ENDNOTEThe concepts of Ludwik Fleck and their application to the eukaryotic cell cycle
Data publikacji: 18.12.2017
Studia Historiae Scientiarum, 2017, 16 (2017), s. 335 - 364
https://doi.org/10.4467/2543702XSHS.17.013.7714Autorzy
The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle
Koncepcje Ludwika Flecka (1896–1961), mikrobiologa, historyka i filozofa medycyny, mogą być użyte do analizowania zjawiska skostnienia idei naukowych. Zagadnienie to omówiono i zastosowano do dominujących koncepcji w rozumieniu cyklu podziału komórek eukariotycznych. Są to: (a) punkt kontrolny fazy G1 (tzw. punkt restrykcyjny) jako element regulacyjny cyklu komórkowego u ssaków; (b) punkt zmiany tempa wzrostu komórek mający występować u drożdży rozszczepkowych (Schizosaccharomyces pombe) oraz (c) postulat, że ekspresja znacznej liczby genów jest zależna od fazy cyklu komórkowego. Fleck zaproponował, że idee naukowe utrwalają się i trudno je zmienić, ponieważ krytyka aktualnych i dominujących modeli jest albo ignorowana, albo przemieniana na poparcie aktualnie obowiązującego modelu. Idea „kolektywu myślowego”, prowadząca do stabilizacji idei naukowych, jest centralnym tematem teorii Ludwika Flecka.
The concepts of Ludwik Fleck (1896–1961), a microbiologist, historian, and philosopher of medicine, can be used to analyze the conservative nature of scientific ideas. This is discussed and applied to ideas dominant in the understanding of the eukaryotic cell cycle. These are (a) the G1-phase restriction point as a regulatory element of the mammalian cell cycle, (b) the Rate Change Point proposed to exist in fission yeast, and (c) the proposal that a large number of genes are expressed in a cell-cycle-dependent manner.
Fleck proposed that scientific ideas become fixed and difficult to change because criticisms of current and dominant models are either ignored or turned to support of the current model. The idea of a thought-collective leading to the stability of scientific ideas is a central theme of the theory of Ludwik Fleck.
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Informacje: Studia Historiae Scientiarum, 2017, 16 (2017), s. 335 - 364
Typ artykułu: Oryginalny artykuł naukowy
Tytuły:
The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle
The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle
The Center for Cell Cycle Analysis (Longboat Key, USA)
University of Michigan Medical School, Department of Microbiology and Immunology, (Ann Arbor, USA)
Publikacja: 18.12.2017
Status artykułu: Otwarte
Licencja: CC BY-NC-ND
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