State of competition: conceptual shoehorning behind priority on calcitonin precursor biosynthesis

Enrique Wulff

Tytuły

Abstrakt

Until the 1950s, the first results in the studies of calcitonin-thyrocalcitonin were ignored in the accepted research scheme. However, it was José Fernández Nonídez from the Spanish School of Histology, died in Augusta (Georgia, USA) in 1947, whose expertise in the parafollicular cells of the mammalian thyroid had led him to an advanced understanding of this separate endocrine organ, which secretes calcitonin. The antecedent of the secretion was present in the cytoplasm of these cells, which Nonídez explained in a paper published in 1932.

In 1973, a Spanish group from the Instituto Gregorio Marañón (Madrid) leading the research into the ectopic production of calcitonin identified the precursor responsible for its biosynthesis. Nonetheless, given the informal power in connection with the communication between the scientists, this significative contribution was absolutely discarded in terms of acknowledgment within their social circle. The services responsible for dissemination of scientific knowledge considered that priority should be given to another group of young scientists dedicated to pro-calcitonin evidence.

The nature and extent of informal communication are highlighted in countries with different measures to guarantee the autonomy and independence of their state powers. Irrespectively of political circumstances, the paper is focused on the competition between two different approaches in science particularly important for progress in medicine: the perspective presented by experimental studies in basic sciences (in animals) and the models developed in clinical sciences.

Stan rywalizacji: priorytetowe znaczenie biosyntezy prekursora kalcytoniny i zniekształcenia pojęciowe

Abstrakt

Do lat 50. XX w. nie uwzględniano w przyjętym schemacie badawczym pierwszych dowodów przemawiających za istnieniem kalcytoniny-tyrokalcytoniny. Jednakże, znajomość przez José Fernándeza Nonídeza (z hiszpańskiej szkoły histologii, który zmarł w Augusta (Georgia, USA) w 1947 r.) komórek pęcherzykowych tarczycy ssaków doprowadziła go do zaawansowanego rozumienia tarczycy jako odrębnego narządu endokrynnego, wydzielającego kalcytoninę. W artykule opublikowanym w 1932 r. Nonídez wyjaśnił, że prekursor wydzielania znajdował się w cytoplazmie komórek tarczycy.

W 1973 r. hiszpańska grupa z Instituto Gregorio Marañón (Madryt), prowadząca badania nad ektopowym wydzielaniem kalcytoniny, zidentyfikowała prekursora odpowiedzialnego za biosyntezę kalcytoniny. Niemniej jednak, biorąc pod uwagę nieformalną władzę związaną z komunikacją między naukowcami, znaczący wkład Nonídeza został absolutnie odrzucony i nie zdobył uznania w tej grupie społecznej. Upowszechnianie usług wiedzy naukowej spowodowało, że przyznano priorytet odkrycia grupie młodych naukowców zajmujących się badaniami pro-kalcytoniny.

Podkreślono charakter i zakres nieformalnej komunikacji w krajach, które wykorzystują różne środki dla zagwarantowania autonomii i niezależności uprawnień państwowych.

Niezależnie od uwarunkowań politycznych artykuł koncentruje się na konkurencji między dwoma różnymi podejściami w nauce, szczególnie ważnymi dla postępu w medycynie: perspektywą przedstawioną w badaniach eksperymentalnych w naukach podstawowych (u zwierząt) i modelach opracowanych w naukach klinicznych.

Until the 1950s, the first results in the studies of calcitonin-thyrocalcitonin were ignored in the accepted research scheme. However, it was José Fernández Nonídez from the Spanish School of Histology, died in Augusta (Georgia, USA) in 1947, whose expertise in the parafollicular cells of the mammalian thyroid had led him to an advanced understanding of this separate endocrine organ, which secretes calcitonin. The antecedent of the secretion was present in the cytoplasm of these cells, which Nonídez explained in a paper published in 1932.

In 1973, a Spanish group from the Instituto Gregorio Marañón (Madrid) leading the research into the ectopic production of calcitonin identified the precursor responsible for its biosynthesis. Nonetheless, given the informal power in connection with the communication between the scientists, this significative contribution was absolutely discarded in terms of acknowledgment within their social circle. The services responsible for dissemination of scientific knowledge considered that priority should be given to another group of young scientists dedicated to pro-calcitonin evidence.

The nature and extent of informal communication are highlighted in countries with different measures to guarantee the autonomy and independence of their state powers. Irrespectively of political circumstances, the paper is focused on the competition between two different approaches in science particularly important for progress in medicine: the perspective presented by experimental studies in basic sciences (in animals) and the models developed in clinical sciences.

Słowa kluczowe

Anatomy, thyroid, endocrinology, Madrid, calcitonin, thyrocalcitonin, pro-calcitonin, Instituto Gregorio Marañón, Jose Fernández Nonídez, conceptual shoehorning, thought collective / anatomia, tarczyca, endokrynologia, Madryt, kalcytonina, tyrokalcytonina, pro-kalcytonina, zniekształcenia pojęciowe, kolektywy myślowe

Anatomy, thyroid, endocrinology, Madrid, calcitonin, thyrocalcitonin, pro-calcitonin, Instituto Gregorio Marañón, Jose Fernández Nonídez, conceptual shoehorning, thought collective

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Informacje

Informacje: Studia Historiae Scientiarum, 2019, 18 (2019), s. 465 - 490

DOI: https://doi.org/10.4467/2543702XSHS.19.013.11019

Typ artykułu: Oryginalny artykuł naukowy

Tytuły:

Polski:

State of competition: conceptual shoehorning behind priority on calcitonin precursor biosynthesis

Angielski:

State of competition: conceptual shoehorning behind priority on calcitonin precursor biosynthesis

Autorzy

Enrique Wulff

https://orcid.org/0000-0001-8104-6147

Instituto de Ciencias Marinas de Andalucía (CSIC) Puerto Real, Cádiz, Spain

Publikacja: 15.11.2019

Status artykułu: Otwarte

Licencja: CC BY-NC-ND

Udział procentowy autorów:

Enrique Wulff (Autor) - 100%

Korekty artykułu:

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Języki publikacji:

Angielski

Liczba wyświetleń: 605

Liczba pobrań: 625

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