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Problems of Forensic Sciences

Limitations of Simon test in new psychoactive substances analysis

Data publikacji: 29.03.2022

Problems of Forensic Sciences (Z Zagadnień Nauk Sądowych), 2021, 126-127, s. 153 - 166

https://doi.org/10.4467/12307483PFS.20.009.15449

Autorzy

,
Kaja Tusiewicz
Department of Forensic Medicine, Wroclaw Medical University, Poland
https://orcid.org/0000-0002-9968-2042 Orcid
Wszystkie publikacje autora →
,
Olga Wachełko
Institute of Toxicology Research, Borowa, Poland
https://orcid.org/0000-0003-4068-2475 Orcid
Wszystkie publikacje autora →
,
Marcin Zawadzki
Department of Forensic Medicine, Wroclaw Medical University, Poland
https://orcid.org/0000-0003-2146-9724 Orcid
Wszystkie publikacje autora →
Paweł Szpot
Department of Forensic Medicine, Wroclaw Medical University, Poland
https://orcid.org/0000-0002-5352-3492 Orcid
Wszystkie publikacje autora →

Abstrakt

New psychoactive substances (NPS) are nowadays a prevalent group of illicit drugs, one of which are synthetic cathinones. The widespread usage of NPS requires fast, reliable, selective and sensitive analytical methods for their identification as well as differentiation. Colorimetric tests are among the most frequently used methods for screening analysis of NPS in forensic sciences because they are fast, cheap and simple they found application in roadside, borders and airport controls, as well as are used for employees control at workplaces. In this paper we present limitations of colorimetric tests based on the example of one of the Simon test’s variant which was used to analyze synthetic cathinones samples. 163 seized drugs samples were analyzed. Used variant of the Simon test comprises reaction of secondary amines with sodium nitroprusside, sodium carbonate and acetaldehyde resulting in deep blue coloration. Our study indicated that the test gives a very low positive results percentage (3%), as well as many false negative results (88%). No pattern in color changes could be observed regarding samples belonging to one group of compounds in order to identify it even when lacking the expected observation. Another important aspects regarding colorimetric test is the fact that observations are very subjective. although this method is fast and easy to perform, it does not provide unambiguous results and thus, they always should be confirmed with the use of other analytical techniques such as LC-MS/MS or GC-MS/MS.

Bibliografia

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Informacje

Informacje: Problems of Forensic Sciences (Z Zagadnień Nauk Sądowych), 2021, s. 153 - 166

Typ artykułu: Oryginalny artykuł naukowy

Tytuły:

Angielski:

Limitations of Simon test in new psychoactive substances analysis

Autorzy

https://orcid.org/0000-0002-9968-2042

Kaja Tusiewicz
Department of Forensic Medicine, Wroclaw Medical University, Poland
https://orcid.org/0000-0002-9968-2042 Orcid
Wszystkie publikacje autora →

Department of Forensic Medicine, Wroclaw Medical University, Poland

https://orcid.org/0000-0003-4068-2475

Olga Wachełko
Institute of Toxicology Research, Borowa, Poland
https://orcid.org/0000-0003-4068-2475 Orcid
Wszystkie publikacje autora →

Institute of Toxicology Research, Borowa, Poland

https://orcid.org/0000-0003-2146-9724

Marcin Zawadzki
Department of Forensic Medicine, Wroclaw Medical University, Poland
https://orcid.org/0000-0003-2146-9724 Orcid
Wszystkie publikacje autora →

Department of Forensic Medicine, Wroclaw Medical University, Poland

https://orcid.org/0000-0002-5352-3492

Paweł Szpot
Department of Forensic Medicine, Wroclaw Medical University, Poland
https://orcid.org/0000-0002-5352-3492 Orcid
Wszystkie publikacje autora →

Department of Forensic Medicine, Wroclaw Medical University, Poland

Publikacja: 29.03.2022

Otrzymano: 24.10.2021

Zaakceptowano: 16.12.2021

Status artykułu: Otwarte __T_UNLOCK

Licencja: CC BY-NC-ND  ikona licencji

Udział procentowy autorów:

Kaja Tusiewicz (Autor) - 25%
Olga Wachełko (Autor) - 25%
Marcin Zawadzki (Autor) - 25%
Paweł Szpot (Autor) - 25%

Korekty artykułu:

-

Języki publikacji:

Angielski, Polski

Liczba wyświetleń: 389

Liczba pobrań: 512