Złocień maruna – starożytny lek na współczesne choroby
cytuj
pobierz pliki
RIS BIB ENDNOTEWybierz format
RIS BIB ENDNOTEZłocień maruna – starożytny lek na współczesne choroby
Data publikacji: 09.2023
Medycyna Nowożytna, 2023, Tom 29 (2023) Zeszyt 1, s. 73 - 88
https://doi.org/10.4467/12311960MN.23.004.18445Autorzy
Złocień maruna – starożytny lek na współczesne choroby
The Feverfew – an ancient remedy for modern diseases
The feverfew (Tanacetum parthenium L.), also known as the Chrysanthemum parthenium, is a perennial plant belonging to the Asteraceae family, growing mainly in gardens and open spaces, can be found growing in the regions of Southern Europe and Asia Minor. The healing effects of feverfew were known in antiquity. In folk medicine, this plant has been used to treat fever, migraine headaches, as well as rheumatoid arthritis, stomach and toothache, and insect bites. The active compounds contained in the feverfew include sesquiterpene lactones, and the most important of them – is parthenolide, which is considered to be the main ingredient determining the biological activity of extracts from this perennial. Feverfew preparations, containing parthenolide, reduce the production of prostaglandins, inhibit the release of serotonin and histamine, and antagonize the 5-HT2A receptors, thus showing the anti-migraine effects. Moreover, feverfew extract has anti-infl ammatory properties and reduces allergy symptoms by inhibiting the secretion of histamine from mast cells. Currently, studies are being conducted on the use of parthenolide in the treatment of neuropathic pain. This type of chronic pain is caused by damage to the somatosensory nervous system, which is observed in the development of diabetes, stroke, cancer, or after mechanical injuries (e.g. as postoperative complications or after traffic accidents). In in vivo studies parthenolide showed a strong analgesic effect, moreover, its use allowed for the reduction of morphine doses in neuropathic animals. This important clinical implication raises great hopes for designing a multimodal therapy for neuropathic pain. In addition to its anti-infl ammatory and analgesic properties, parthenolide exhibits antitumor activity by inhibiting the NF-κB and STAT transcription factors and inducing the permanent activation of JNK kinase and p53 protein, thereby sensitizing neoplastic cells to radio- and chemotherapy. Interestingly, parthenolide induces apoptosis of cancer cells but has no toxic effects on normal cells. Currently, preparations from the feverfew are used in the phytotherapy of migraine headaches, however, the results of the preclinical research open up new perspectives for the use of this perennial, in particular parthenolide, in modern therapy.
Alenzi K.A., Alharbi F.H., Tawhari F.M., Fradees G.S., Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium), “J Med Cases” 2021, Jan., nr 12(1).
Apteczka lekarstw domowych, które każdy człowiek maiąc w niebytności Medyka snadno zdrowia poratować może. Tak z ziół iako też y z zwierząt bardzo doświadczone, tak dla Ludzi iako y dla była zebrana y przedrukowana w Lublinie w drukarni J.K.M. Societatis Jesu Roku Pańskiego 1754.
Bahrami M., Kamalinejad M., Latifi S.A., Seif F., Dadmehr M., Cytokine storm in COVID-19 and parthenolide: Preclinical evidence, “Phytother. Res.” 2020, nr 10.
Carlisi D., D’Anneo A., Angileri L., Lauricella M., Emanuele S., Santulli A., Vento R., Tesoriere G., Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation, “J. Cell. Physiol.” 2011, nr 226.
35 M. Bahrami, M. Kamalinejad, S.A. Latifi , F. Seif, M. Dadmehr, Cytokine storm in COVID-19 and parthenolide: Preclinical evidence, “Phytother. Res.” 2020, nr 10, s. 1002.
Carlisi D., Lauricella M., D’Anneo A., De Blasio A., Celesia A., Pratelli G., Notaro A., Calvaruso G., Giuliano M., Emanuele S., Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties, “Biomedicines” 2022, Feb 21, nr 10.
Colloca L., Ludman T., Bouhassira D., Baron R., Dickenson A.H., Yarnitsky D., Freeman R., Truini A., Attal N., Finnerup N.B., Eccleston C., Kalso E., Bennett D.L., Dworkin R.H., Raja S.N., Neuropathic pain, “Nat Rev Dis Primers” 2017, Feb 16, nr 3.
Finnerup N.B., Haroutounian S., Kamerman P., Baron R., Bennett D.L.H., Bouhassira D., Cruccu G., Freeman R., Hansson P., Nurmikko T., Raja S.N., Rice A.S.C., Serra J., Smith B.H., Treede R.D., Jensen T.S., Neuropathic pain: an updated grading system for research and clinical practice, “Pain.” 2016, Aug, nr 157(8).
Hayes N.A., Foreman J.C., The activity of compounds extracted from feverfew on histamine release from rat mast cells, “J Pharm Pharmacol.” 1987, nr 39.
https://www.who.int/initiatives/who-global-centre-for-traditionalmedicine.
John Hill, The British herbal: an history of plants and trees, natives of Britain, cultivated for use or raised for beauty, https://www.biodiversitylibrary.org/item/108521#page/3/mode/1up.
Johnson E.S., Kadam N.P., Hylands D.M., Hylands P.J., Efficacy of feverfew as prophylactic treatment of migraine, “BMJ” 1985, nr 291.
Kruk P.J., Beneficial effect of additional treatment with widely available anticancer agents in advanced small lung cell carcinoma: A case report, “Mol Clin Oncol.” 2018, nr 9(6).
Knight D.W., Feverfew: Chemistry and biological activity, “Nat Prod Rep.” 1995, nr 12(3).
Kwok B.H., Koh B., Ndubuisi M.I., Elofsson M., Crews C.M., The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkB kinase, “Chem. Biol.” 2001, nr 8.
Lipton R.B., Bigal M.E., Diamond M., Freitag F., Reed M.L., Stewart W.F., Migraine prevalence, disease burden, and the need for preventive therapy, “Neurology” 2007, nr 68.
Loh Ch.Y., Arya A., Naema A.F., Won Fen Wong W.F., Sethi G., Looi Ch.Y., Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication, “Front Oncol.” 2019, Feb. 21, nr 9.
Marcin Siennik, Herbarz to iest Zioł tutecznych, postronnych, y Zamorskich opisanie: co za moc maią, a iako ich vżywać, tak ku przestrzeżeniu zdrowia ludzkiego, iako ku vzdrowieniu rozmaitych chorob: Teraz nowo, wedle Herbarzow dzisieyszego wieku, y innych zacnych Medykow, poprawiony. Przydano Alexego Pedemontana Księgi ośmiory, o taiemnych a skrytych Lekarstwiech. Przy czym dosyć misternych a trafnych rzeczy y doświadczonych mieć będziesz. Co się w tych Księgach więcey opisuie, zarazem po Epistole znaydziesz: a gdyć czego szukać potrzeba, Regestra dostateczne na końcu snadnieć pokażą. W Krakowie, w Drukarni Mikołaja Szarffenberga. Roku Pańskiego 1568.
Mendonca M.S., Chin-Sinex H., Gomez-Millan J., Datzman N., Hardacre M., Comerford K., Nakshatri H., Nye M., Benjamin L., Mehta S., Patino F., Sweeney C., Parthenolide sensitizes cells to X-ray- induced cell killing through inhibition of NF-kB and split-dose repair, “Radiat. Res.” 2007, nr 168.
Pareek A., Suthar M., Rathore G.S., Feverfew (Tanacetum parthenium L.): A systematic review, “Bansal Pharmacogn Rev.” 2011, nr 5(9).
Popiolek-Barczyk K., Makuch W., Rojewska E., Pilat D., Mika J., Inhibition of intracellular signaling pathways NF-κB and MEK1/2 attenuates neuropathic pain development and enhances morphine analgesia, “Pharmacological Reports” 2014, nr 66.
Popiolek-Barczyk K., Kolosowska N., Piotrowska A., Makuch W., Rojewska E., Jurga A.M., Pilat D., Mika J., Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy, “Neural Plasticity” 2015.
Przepisy lekarskie i gospodarskie, XIX w., Lwowska Naukowa Biblioteka im. W. Stefanyka NAN Ukrainy, f. 45, rkps 239.
Ralstin M.C., Gage E.A., Yip-Schneider M.T., Klein P.J., Wiebke E.A., Schmidt C.M., Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest, “Mol. Cancer Res.” 2006, nr 4.
Sobota R., Szwed M., Kasza A., Bugno M., Kordula T., Parthenolide inhibits activation of signal transducers and activators of transcription (STATs) induced by cytokines of the IL-6 family, “Biochem. Biophys. Res. Commun.” 2000, nr 267.
Stefan Falimirz, O ziołach i o mocy ich, Kraków 1534.
Studzińska-Sroka E., Znajdek-Awizeń P., Gawron-Gzella A., Studies on the antimigraine action of Feverfew (Tanacetum parthenium (L.) Sch. Bip.), “Wiad. Lek.” 2013, nr 66(2 Pt 2).
Tassorelli C., Greco R., Morazzoni P., Riva A., Sandrini G., Nappi G., Parthenolide is the component of Tanacetum parthenium that inhibits nitroglycerin-induced Fos activation: studies in an animal model of migraine, “Cephalalgia” 2005, nr 25.
Yip-Schneider M.T., Nakshatri H., Sweeney C.J., Marshall M.S., Wiebke
E.A., Schmidt C.M., Parthenolide and sulindac cooperate to mediate growth suppression and inhibit the nuclear factor-kappa B pathway in pancreatic carcinoma cells, “Mol. Cancer Ther.” 2005, nr 4.
Weber J.T., O’Connor M.F., Hayataka K., Colson N., Medora R., Russo E.B., Parker K.K., Activity of parthenolide at 5HT2A receptors, “J Nat Prod.” 1997, nr 60.
Wider B., Pittler M.H., Ernst E., Feverfew for Preventing Migraine, “The Cochrane database of systematic reviews” 2015, nr 4.
Veitch N.C., Smith M., Barnes J., Anderson L.A., Phillipson J.D., Herbal medicine. 4th ed., Pharmaceutical Press, London, UK 2013.
Zielnik z XVIII w., Zakład Narodowy im. Ossolińskich we Wrocławiu.
Informacje: Medycyna Nowożytna, 2023, Tom 29 (2023) Zeszyt 1, s. 73 - 88
Typ artykułu: Oryginalny artykuł naukowy
Tytuły:
Złocień maruna – starożytny lek na współczesne choroby
The Feverfew – an ancient remedy for modern diseases
Publikacja: 09.2023
Status artykułu: Otwarte
Licencja: Żadna
Udział procentowy autorów:
Korekty artykułu:
-Języki publikacji:
PolskiLiczba wyświetleń: 443
Liczba pobrań: 351