The sequential explanatory design is one of the possible procedures for implementing mixed methods research. Within one study, both quantitative and qualitative approaches are used, but the collection and analysis of data in the quantitative phase precede the collection and analysis of data in the qualitative phase. The scheme is presented from the perspective of media studies and political science, using the example of researching digitized voters-users. The main goal of the article is to provide a methodological reflection on the sequential explanatory design and indicate the procedure, possibilities, and benefits of its use. Crucial methodological challenges that accompany the research process have been identified, focusing on topics such as the role of the researcher, the preparation of the study, and its course. The ethical aspect of the conducted research is highlighted. The article also presents several recommendations for researchers implementing the sequential explanatory design.