The overview of forensic genetic genealogy
cytuj
pobierz pliki
RIS BIB ENDNOTEChoose format
RIS BIB ENDNOTEThe overview of forensic genetic genealogy
Publication date: 21.04.2023
Archives of Forensic Medicine and Criminology, 2022, Vol. 72 (4), pp. 211 - 222
https://doi.org/10.4467/16891716AMSIK.22.023.17623Authors
The overview of forensic genetic genealogy
Forensic genetic genealogy (FGG) benefits largely from popularity of genealogical research within (mostly) American society and the advent of new sequencing techniques that allow typing of challenging forensic samples. It is considered a true breakthrough for both active and especially cold cases where all other resources and methods have failed during investigation. Despite media coverage generally highlighting its powers, the method itself is considered very laborious and the investigation may easily got suspended at every stage due to many factors including no hits in the database or breaks in traceable lineages within the family tree. This review summarizes the scope of FGG use, mentions most concerns and misconceptions associated with the technique and points to the plausible solutions already suggested. It also brings together current guidelines and regulations intended to be followed by law enforcement authorities wishing to utilize genetic genealogy research
Williams R, Wienroth M. Social and ethical aspects of forensic genetics: A critical review. Forensic Sci Rev. 2017 Jul;29(2):145–69.
Zieger M. Forensic DNA phenotyping in Europe: How far may it go? J Law Biosci. 2022 Jul 1;9(2):lsac024.
SR 363 –Federal Act of 20 June 2003 on the Use of DNA Profiles in Criminal Proceedings and for Identifying Unidentified or Missing Persons (DNA Profiles Act) [Internet]. [cited 2023 Mar 29]. Available from: https://www.fedlex.admin.ch/eli/cc/2004/811/en
Glynn CL. Bridging Disciplines to Form a New One: The Emergence of Forensic Genetic Genealogy. Genes. 2022 Aug 1;13(8): 1381.
Edge MD, Coop G. Donnelly (1983) and the limits of genetic genealogy. Theor Popul Biol. 2020 Jun;133:23–4.
Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, et al. Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Res. 2011 May;21(5):768–74.
Henn BM, Hon L, Macpherson JM, Eriksson N, Saxonov S, Pe’er I. , et al. Cryptic Distant Relatives Are Common in Both Isolated and Cosmopolitan Genetic Samples. PLOS ONE. 2012 Apr 3;7(4):e34267.
Bettinger BT. The Shared cM Project Version 4.0 (March 2020). 2020;
Mateen RM, Sabar MF, Hussain S, Parveen R, Hussain M. Familial DNA analysis and criminal investigation: Usage, downsides and privacy concerns. Forensic Sci Int. 2021 Jan;318:110576.
Fortier AL, Kim J, Rosenberg NA. Human-Genetic Ancestry Inference and False Positives in Forensic Familial Searching. G3 GenesGenomesGenetics. 2020 Jun 25;10(8):2893–902.
Laurent FX, Fischer A, Oldt RF, Kanthaswamy S, Buckleton JS, Hitchin S. Streamlining the decision-making process for international DNA kinship matching using Worldwide allele frequencies and tailored cutoff log10LR thresholds. Forensic Sci Int Genet. 2022 Mar 1;57:102634.
Bowen S, Khoury M. Consumer genetic testing is booming: but what are the benefits and harms to individuals and populations? CDC, Cent DisCont rol: Genom Precis Health [Internet]. 2018 [cited 2023 Jan 31]; Available from: https://blogs.cdc.gov/genomics/2018/06/12/consumer-genetic-testing/
Autosomal DNA testing comparison chart [Internet]. Available from: https://isogg.org/wiki/Autosomal_DNA_testing_comparison_chart
Peck MA, Koeppel AF, Gorden EM, Bouchet JL, Heaton MC, Russell DA, et al. Internal Validation of the ForenSeq Kintelligence Kit for Application to Forensic Genetic Genealogy. Forensic Genomics. 2022 Dec;2(4):103–14.
Transparency report [Internet]. 2023 [cited 2023 Feb 3]. Available from: https://www.23andme.com/en-int/transparency-report/
Ball CA, Barber MJ, Byrnes J, Carbonetto P, Curtis RE, Granka JM, et al. Discovering genetic matches across a massive, expanding genetic database. 2020 [cited 2023 Feb 3]; Available from: https://www.ancestrycdn.com/support/us/2020/08/matchingwhitepaper.pdf
Ellenbogen P, Narayanan A. Identification of Anonymous DNA Using Genealogical Triangulation [Internet]. bioRxiv; 2019 [cited 2023 Feb 3]. p. 531269. Available from: https://www.biorxiv.org/content/10.1101/531269v1
SWGDAM, Overview of investigative genetic genealogy [Internet]. 2020 [cited 2023 Jan 23]. Available from: https://www.swgdam.org/publications
Kennett D. Using genetic genealogy databases in missing persons cases and to develop suspect leads in violent crimes. Forensic Sci Int. 2019 Aug 1;301:107–17.
Russell DA, Gorden EM, Peck MA, Neal CM, Heaton MC, Bouchet JL, et al. Developmental Validation of the Illumina Infinium Assay Using the Global Screening Array on the iScan System for Use in Forensic Laboratories. Forensic Genomics. 2023 Mar;3(1):15–24.
de Vries JH, Kling D, Vidaki A, Arp P, Kalamara V, Verbiest MMPJ, et al. Impact of SNP microarray analysis of compromised DNA on kinship classification success in the context of investigative genetic genealogy. Forensic Sci Int Genet. 2022 Jan 1;56:102625.
Hui R, D’Atanasio E, Cassidy LM, Scheib CL, Kivisild T. Evaluating genotype imputation pipeline for ultra-low coverage ancient genomes. Sci Rep. 2020 Oct 29;10(1):18542.
Nagraj V p., Scholz M, Jessa S, Ge J, Huang M, Woerner AE, et al. Relationship Inference with Low-Coverage Whole Genome Sequencing on Forensic Samples. Forensic Genomics. 2022 Sep;2(3):81–91.
Kling D. On the use of dense sets of SNP markers and their potential in relationship inference. Forensic Sci Int Genet. 2019 Mar 1;39:19–31.
Skare O, Sheehan N, Egeland T. Identification of distant family relationships. Bioinforma Oxf Engl. 2009 Sep 15;25(18):2376–82.
Mitchell R, Enke S, Eskey K, Ferguson T, Just R. A method to enable forensic genetic genealogy investigations from DNA mixtures. Forensic Sci Int Genet Suppl Ser. 2022 Dec;8:159–61.
Kling D, Phillips C, Kennett D, Tillmar A. Investigative genetic genealogy: Current methods, knowledge and practice. Forensic Sci Int Genet. 2021 May 1;52:102474.
Browning SR, Browning BL. High-resolution detection of identity by descent in unrelated individuals. Am J Hum Genet. 2010 Apr 9;86(4):526–39.
Kong A, Masson G, Frigge ML, Gylfason A, Zusmanovich P, Thorleifsson G, et al. Detection of sharing by descent, long-range phasing and haplotype imputation. Nat Genet. 2008 Sep;40(9):1068–75.
Li H, Glusman G, Huff C, Caballero J, Roach JC. Accurate and Robust Prediction of Genetic Relationship from Whole-Genome Sequences. PLoS ONE [Internet]. 2014 [cited 2023 Feb 1];9(2). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938395/
Manichaikul A, Mychaleckyj JC, Rich SS, Daly K, Sale M, Chen WM. Robust relationship inference in genome-wide association studies. Bioinforma Oxf Engl. 2010 Nov 15;26(22):2867–73.
Weir BS, Anderson AD, Hepler AB. Genetic relatedness analysis: modern data and new challenges. Nat Rev Genet. 2006 Oct;7(10):771–80.
McPeek MS, Sun L. Statistical tests for detection of misspecified relationships by use of genome-screen data. Am J Hum Genet. 2000 Mar;66(3):1076–94.
Thompson EA. Statistical Inference from Genetic Data on Pedigrees. NSF-CBMS Reg Conf Ser Probab Stat. 2000;6:i–169.
Thompson EA. Identity by descent: variation in meiosis, across genomes, and in populations. Genetics. 2013 Jun;194(2):301–26.
Kling D, Tillmar A. Forensic genealogy—A comparison of methods to infer distant relationships based on dense SNP data. Forensic Sci Int Genet. 2019 Sep 1;42:113–24.
Erturk MS, Fitzpatrick C, Press M, Wein LM. Analysis of the genealogy process in forensic genetic genealogy. J Forensic Sci. 2022 Nov;67(6):2218–29.
Cady J, Greytak EM. Whole-genome sequencing of degraded DNA for investigative genetic genealogy. Forensic Sci Int Genet Suppl Ser. 2022 Dec;8:20–2.
Dowdeswell TL. Forensic genetic genealogy: A profile of cases solved. Forensic Sci Int Genet. 2022 May 1;58:102679.
Ram N, Roberts JL. Forensic genealogy and the power of defaults. Nat Biotechnol. 2019 Jul;37(7):707–8.
Wickenheiser RA. Forensic genealogy, bioethics and the Golden State Killer case. Forensic Sci Int Synergy. 2019;1:114–25.
Murray K. “NorCal”rapist Roy Waller sentenced to 897 years [Internet]. CNN. 2020 [cited 2023 Feb 3]. Available from: https://www.cnn.com/2020/12/18/us/norcal-rapist-roy-waller-sentenced-trnd/index.html
Boy in the box philadelphia homicide. [cited 2023 Jan 23]; Available from: https://www.nytimes.com/2022/12/08/us/boy-in-the-box-philadelphia-homicide.html
Greytak EM, Moore C, Armentrout SL. Genetic genealogy for cold case and active investigations. Forensic Sci Int. 2019 Jun 1;299:103–13.
United States Department of Justice Interim Policy: Forensic Genetic Genealogical DNA Analysis and Searching.
Callaghan TF. Responsible genetic genealogy. Science. 2019 Oct 11;366(6462):155.
Should we be making use of genetic genealogy to assist in solving crime? A report on the feasibility of such methods in the UK.
Maguire CN, McCallum LA, Storey C, Whitaker JP. Familial searching: A specialist forensic DNA profiling service utilising the National DNA DatabaseR to identify unknown offenders via their relatives—The UK experience. Forensic Sci Int Genet. 2014 Jan 1;8(1):1–9.
Thomson J, Clayton T, Cleary J, Gleeson M, Kennett D, Leonard M, et al. The effectiveness of forensic genealogy techniques in The united kingdom –an experimental assessment. Forensic Sci Int Genet Suppl Ser. 2019 Dec 1;7(1):765–7.
Tillmar A, Fagerholm SA, Staaf J, Sjolund P, Ansell R. Getting the conclusive lead with investigative genetic genealogy –A successful case study of a 16 year old double murder in Sweden. Forensic Sci Int Genet. 2021 Jul 1;53:102525.
The Swedish Police Authority, National Forensic Centre. Forensic DNA Traces and Genealogy. Use of investigative genetic genealogy in criminal investigations [Internet]. 2021 [cited 2023 Feb 2]. Available from: https://polisen.se/SysSiteAssets/dokument/forensik/forensic-dna-traces-and-genealogy.pdf.
Guerrini CJ, Wickenheiser RA, Bettinger B, McGuire AL, Fullerton SM. Four misconceptions about investigative genetic genealogy. J Law Biosci. 2021 Apr 10;8(1):lsab001.
McEwen J, Pino N, Raphael A, Renna K, Boyer J, Brody LC. Investigative Genetic Genealogy: Ethical, Legal, and Social Issues and Directions for Future Research. Forensic Genomics. 2021 Sep;1(3):91–8.
Guerrini CJ, Robinson JO, Petersen D, McGuire AL. Should police have access to genetic genealogy databases? Capturing the Golden State Killer and other criminals using a controversial new forensic technique. PLoS Biol [Internet]. 2018 Oct [cited 2023 Feb 1];16(10). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168121/
Gurney D, Press M, Moore C, Rolnick CI, Hochreiter A, Bossert BL. The need for standards and certification for investigative genetic genealogy, and a notice of action. Forensic Sci Int. 2022 Dec;341:111495.
Information: Archives of Forensic Medicine and Criminology, 2022, Vol. 72 (4), pp. 211 - 222
Article type: Original article
Titles:
The overview of forensic genetic genealogy
Sądowa genealogia genetyczna – przegląd zagadnień
Department of Forensic Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń
Poland
Published at: 21.04.2023
Received at: 06.02.2023
Accepted at: 29.03.2023
Article status: Open
Licence: CC-BY-NC-SA
Percentage share of authors:
Article corrections:
-Publication languages:
English, PolishSuggested citations: Nature