This article analyses the work of Laurent Mignonneau and Christa Sommerer. They are perceived by new media art researchers as pioneers of interactive art and placed in the context of interface culture – an artistic, research and educational project they created and implemented for many years. The author of the article argues that the pioneering and innovative status of Mignonneau and Sommerer’s art goes far beyond creativity in the field of interfaces and interactivity itself. It emerges from the multidirectional relations between various aspects of new media art present in their works, combining interactivity with participation, generativity, performativity, embodiment, immersion and virtuality. Second-order cybernetics and cybernetic art, as well as theories of complexity and self-regulating systems, are extremely important contexts for the proper interpretation of the nature and role of interactivity in their work. Transdisciplinary relations between art, science and technology create an integrating framework for all of them.