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Acanthamoeba in the Domestic Water Supply of Huntington, West Virginia, U.S.A.

Publication date: 2010

Acta Protozoologica, 2010, Volume 49, Issue 1 , pp. 9 - 15

Authors

,
Wendy Trzyna
Department of Biological Sciences, Marshall University, Huntington, WV, USA
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,
Margaret W. Mbugua
Department of Biological Sciences, Marshall University, Huntington, WV, USA
All publications →
Andrew Rogerson
California State University Fresno, CA, USA
All publications →

Titles

Acanthamoeba in the Domestic Water Supply of Huntington, West Virginia, U.S.A.

Abstract

The aim of this study was to determine the prevalence of Acanthamoeba in the domestic water supply in Huntington, West Virginia (U.S.A.) and the factors that may contribute to their presence or absence. One hundred sixty-two one liter tap water samples were collected over eight months. Amoebae in the samples (cysts or trophozoites) were harvested by passively filtering onto 5 μm pore size filters and enriching for amoebae on non-nutrient amoeba saline agar plates seeded with Escherichia coli for cultivation. Thirteen percent of all samples were positive for amoebae and 9.3% were positive for the amoeba of interest, Acanthamoeba. Chlorine levels were determined for samples at the time of collection, yielding a mean level of 1.56 mg l–1 chlorine in the distribution system ca. 8 kilometers from the water treatment plant. Cysts and trophozoites of Acanthamoeba clonal isolates were found to tolerate up to 50 mg l–1 and 4 mg l–1 chlorine respectively. This study showed that Acanthamoeba were present in the domestic water supply in Huntington, WV and although no attempt was made to count cells in liter samples, their frequency of occurrence (9.3%) and failure to be present in all replicates, suggests they were present at background levels of perhaps a few cells per five liters. This is only the second U.S. study to consider amoebae in tap water and is unique since the source water was river water. Acanthamoeba trophozoites and cysts were able to withstand levels of chlorine higher than those typically found in tap water suggesting they may be present in either form in the distribution system. Acanthamoeba are opportunistic pathogens capable of causing eye infections and their presence in tap water is a potential risk factor for susceptible individuals, particularly contact lens wearers who may use tap water to clean lenses and storage cases.

References

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Boost M., Cho P., Lai S., Sun W. M. (2008) Detection of Acanthamoeba in tap water and contact lens cases using polymerase chain reaction. Optom. Vis. Sci. 85: 526–530

Booton G. C., Kelly D. J., Chu Y.-W., Seal D. V., Houang E., Lam D. S. C., Byers T. J. and Fuerst P. A. (2002) 18S Ribosomal DNA typing and tracking of Acanthamoeba species isolates from corneal scrape specimens, contact lenses, lens cases and home water supplies of Acanthamoeba keratitis patients in Hong Kong. J. Clin. Microbiol. 40: 1621–1625

Booton G. C., Rogerson A., Bonilla T. D., Seal D. V., Kelly D. J., Beattie T. K., Tomlinson A., Lares-Villa F., Fuerst, P. A. and Byers T. J. (2004) Molecular and physiological evaluation of subtropical environmental isolates of Acanthamoeba spp., causal agent of Acanthamoeba keratitis. J. Eukaryot. Microbiol. 51: 192–200

Houang E., Lam D., Fan D., Seal D. (2001) Microbial keratitis in Hong Kong: relationship to climate, environment and contactlens disinfection. Trans. R. Soc. Trop. Med. Hyg. 95: 361–367

Jeong H. J., Yu H. S. (2005) The role of domestic tap water in Acanthamoeba contamination in contact lens storage cases in Korea. Korean J. Parasitol. 43: 47–50

Johnston S. P., Sriram R., Qvarnstrom Y., Roy S., Verani J., Yoder J., Lorick S., Roberts J., Beach M. J., Visvesvara G. (2009) Resistance of Acanthamoeba cysts to disinfection in multiple contact lens solutions. J. Clin. Microbiol. 47: 2040–2045

Kilvington S., Anger C. (2001) A comparison of cyst age and assay method of the efficacy of contact lens disinfectants against Acanthamoeba. Br. J. Ophthalmol. 85: 336–340

Kilvington S., Gray T., Dart J., Morlet N., Beeching J. R., Frazer D. G., Matheson M. (2004) Acanthamoeba keratitis: the role of domestic tap water contamination in the United Kingdom. Invest Ophthalmol. Vis. Sci. 45: 165–169

Kong H. H., Shin J. Y., Yu H. S., Kim J., Hahn T. W., Hahn Y. H., Chung D. I. (2002) Mitochondrial DNA restriction fragment length polymorphism (RFLP) and 18S small-subunit ribosomal DNA PCR-RFLP analyses of Acanthamoeba isolated from contact lens storage cases of residents in southwestern Korea. J. Clin. Microbiol. 40: 1199–1206

Lam D. S., Houang E., Fan D. S., Lyon D., Seal D., Wong E. (2002) Hong Kong Microbial Keratitis Study Group. Incidence and risk factors for microbial keratitis in Hong Kong: comparison with Europe and  North America. Eye. 16: 608–618

Laskowski-Arce M. A., Orth K. (2008) Acanthamoeba castellanii promotes the survival of Vibrio parahaemolyticus. Appl. Environ. Microbiol. 74: 7183–7188. Epub 2008 Oct 10

Ledee D. R., Iovieno A., Miller D., Mandal N., Diaz M., Fell J., Fini M. E., Alfonso E. C. (2009) Molecular identification of T4 and T5 genotypes in isolates from Acanthamoeba keratitis patients. J. Clin. Microbiol. 47: 1458–1462

Marciano-Cabral F., Cabral G. (2003) Acanthamoeba spp. as agents of disease in humans. Clin. Microbiol. Rev. 16: 273–307

Page F. C. (1988) A new key to freshwater and soil Gymnamoebae. Freshwater Biol. Ass., Ambleside, Cumbria 

Schroeder J. M., Booton G. C., Hay J., Niszl I. A., Seal D. V., Markus M. B., Fuerst P. A., Byers T.  J. (2001) Use of subgenic 18S ribosomal DNA PCR and sequencing for genus and genotype identification of acanthamoebae from humans with keratitis and from sewage sludge. J. Clin. Microbiol. 39: 1903–1911

Seal D. V. (2003) Acanthamoeba keratitis update-incidence, molecular epidemiology and new drugs for treatment. Eye. 17: 893–905

Seal D. V., Kirkness C. M., Bennett H. G., Peterson M. (1999) Acanthamoeba keratitis in Scotland: risk factors for contact lens wearers. Cont. Lens. Anterior. Eye. 22: 58–68

Seal D. V., Bron A. J. and Hay J. (1998) Ocular Infection. Investigation and Treatment in Practice. Martin Dunitz Ltd., London, United Kingdom

Seal D. V., Stapleton F. and Dart J. (1992) Possible environmental sources of Acanthamoeba spp. in contact lens wearers. Br. J. Ophthalmol. 76: 424–427

Shoff M. E., Rogerson A., Kessler K., Schatz S., Seal D. V. (2008) Prevalence of Acanthamoeba and other naked amoebae in South Florida domestic water. J. Water. Health. 6: 99–104

Shoff M., Rogerson A., Schatz S., Seal D. (2007) Variable responses of Acanthamoeba strains to three multipurpose lens cleaning solutions. Optom. Vis. Sci. 84: 202–207

Sun X., Zhang Y., Li R., Wang Z., Luo S., Gao M., Deng S., Chen W., Jin X. (2006) Acanthamoeba keratitis: clinical characteristics and management. Ophthalmology 113: 412–416

Thomas V., McDonnell G., Denyer S. P., Maillard J. Y. (2009) Freeliving amoebae and their intracellular pathogenic microorganisms: risks for water quality. FEMS Microbiol Rev. Aug 12. [Epub ahead of print]

Thomas V., Loret J. F., Jousset M., Greub G. (2008) Biodiversity of amoebae and amoebae-resisting bacteria in a drinking water treatment plant. Environ. Microbiol. 10: 2728–2745

Turner N. A., Russell A. D., Furr J. R., Lloyd D. (2000) Emergence of resistance to biocides during differentiation of Acanthamoeba castellanii. J. Antimicrob. Chemother. 46: 27–34

Xuan Y. H., Yu H. S., Jeong H. J., Seol S. Y., Chung D. I., Kong H. H. (2007) Molecular characterization of bacterial endosymbionts of Acanthamoeba isolates from infected corneas of Korean patients. Korean J. Parasitol. 45: 1–9 

Zhang Z., Schwartz S., Wagner L., and Miller W. (2000) A greedy algorithm for aligning DNA sequences, J. Comput. Biol. 7: 203–214

Information

Information: Acta Protozoologica, 2010, Volume 49, Issue 1 , pp. 9 - 15

Article type: Original article

Authors

Department of Biological Sciences, Marshall University, Huntington, WV, USA

Department of Biological Sciences, Marshall University, Huntington, WV, USA

California State University Fresno, CA, USA

Published at: 2010

Article status: Open

Licence: None

Percentage share of authors:

Wendy Trzyna (Author) - 33%
Margaret W. Mbugua (Author) - 33%
Andrew Rogerson (Author) - 34%

Article corrections:

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Publication languages:

English

View count: 1812

Number of downloads: 1207