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Occurrence of anti-cancer drugs in the aquatic environment and efficiency of their removal ‒ the selected issues

Data publikacji: 11.02.2015

Czasopismo Techniczne, 2014, Środowisko Zeszyt 1-Ś (20) 2014, s. 11 - 18

https://doi.org/10.4467/2353737XCT.14.322.3410

Autorzy

,
Wojciech Balcerzak
Institute of Water Supply and Environmental Protection, Faculty of Environmental Engineering, Cracow University of Technology
Wszystkie publikacje autora →
Piotr Rezka
Institute of Water Supply and Environmental Protection, Faculty of Environmental Engineering, Cracow University of Technology
Wszystkie publikacje autora →

Tytuły

Occurrence of anti-cancer drugs in the aquatic environment and efficiency of their removal ‒ the selected issues

Abstrakt

The article discusses the occurrence of selected cytostatic drugs in the aquatic environment. The authors start with a preliminary introduction to the characteristics of the most commonly used cytostatic drugs. Then, based on the review of the literature they show that such drugs occur in small amounts in an aqueous medium and that there is no reliable research data on the long-term exposure of aquatic organisms to cytostatics. Until now, the studies on the stability of some cytostatics showed that these compounds were extremely stable, not only in natural waters, but also at wastewater treatment plants (WWTPs). In spite of the advanced treatment technologies used at wastewater treatment plants, cytostatics pass relatively easily through the treatment line and end up in surface waters, thus posing a threat to water quality.

Bibliografia

Benotti M.J., Trenholm R.A., Vanderford B.J., Holady J.C., Stanford, B.D., Snyder, S.A., Pharmaceuticals and endocrine disrupting compounds in U.S. drinking water, Environmental Science & Technology, Vol. 43, 2009, 597-603.

Booker V., Halsall C., Llewellyn N., Johnson A., Williams R., Prioritising anticancer drugs for environmental monitoring and risk assessment purposes, Science of the Total Environment, Vol. 473‒474, 2014, 159-170.

Buerge I.J., Buser H.R., Poiger T., Muller M.D., Occurrence and fate of the cytostatic drugs cyclophosphamide and ifosfamide in wastewater and surface waters, Environmental Science & Technology, Vol. 40, 2006, 7242-7250.

Buntner D., Żabczyński S., Miksch K., Usuwanie farmaceutyków ze ścieków, Chemik, Vol. 60, 2007, 120-124.

Chen M., Ohman K., Metcalfe C., Ikonomou M.G., Amatya P.L., Wilson J., Pharmaceuticals and endocrine disruptors in wastewater treatment effluents and in the water supply system of Calgary, Alberta, Canada, Water Quality Research Journal of Canada, Vol. 41, 2006, 351-364.

Green R.E., Taggart M.A., Senacha K.R., Raghavan B., Pain D.J., Jhala Y., Cuthbert R., Rate of decline of the oriental white-backed vulture population in India estimated from a survey of diclofenac residues in carcasses of ungulates, PLoS ONE 2, 2007.

Heberer T., Occurrence, fate, and removal of pharmaceuticals residues in the aquatic environmentl a review of recent research data, Toxicology Letters, Vol. 131, 2002, 5-17.

Jobling S., Williams R., Johnson A., Taylor A., Gross-Sorokin M., Nolan M., Tyler C.R., van Aerle R., Santos E., Brighty G., Predicted exposures of steroid estrogens in U.K. rivers correlate with widespread sexual disruption in wild fish populations, Environmental Health Perspectives, Vol. 114, 2006, 32-39.

Kidd K.A., Blanchfield P.J., Mills K.H., Palace V.P., Evans R.E., Lazorchak J.M., Flick R.W., Collapse of a fish population after exposure to a synthetix estrogen, Proceedings of the National Academy of Sciences of the U.S.A., Vol. 104, 2007, 8997-8901.

Kiffmeyer T., Gotze H.J., Jursh M., Luders U., Trace enrichment, chromatographic separation and biodegradation of cytostatic compounds in surface water, Fresenius’ Journal of Analytical Chemistry, Vol. 361, 1998, 185-191.

Kummerer K., Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources – a review, Chemosphere, Vol. 45, 2001, 957-969.

Kummerer K., Pharmaceuticals in the environment, Annual Review of Environment and Resources, Vol. 35, 2010, 57-75.

Kummerer K., Al-Ahmad A., Bertram B., Wiessler M., Biodegradability of antineoplastic compounds in screening test: influence of glucosidation and of stereochemistry, Chemosphere, Vol. 40, 2000, 767-773.

Kummerer K., Steger-Hartmann T., Meyer M., Biodegradability of the anti-tumor agent ifosfamide and its occurrence in hospital effluents and communal sewage, Water Research, Vol. 31, 1997, 2705-2710.

Lange R., Hutchinson T.H., Croudace C.P., Siegmund F., Schweinfurth H., Hampe P., Panter G.H., Sumpter J.P., Effects of the synthetic estrogen 17-alpha-ethinylestradiol on the life- -cycle of the fathead minnow (Pimephales promelas), Environmental Toxicology and Chemistry, Vol. 20, 2006, 1216-1227.

Li W.C., Occurrence, sources, and fate of pharmaceuticals in aquatic environment and soil, Environmental Pollution, No. 187, 2014, 193-201.

Lin A.Y.-C., Lin Y.-C., Lee W.-N., Prevalence and sunlight photolysis of controlled and chemotherapeutic drugs in aqueous environments, Environmental Pollution, No. 187, 2014, 170-181.

Lin A.Y.-C., Lin H.H.-H., Photocatalytic oxidation of 5-fluorouracil and cyclophosphamide via UV/TiO2 in an aqueous environment, Water Research, No. 48, 2014, 559-568.

Lin A.Y.-C., Wang X.-W., Lee W.-N., Phototransformation determines the fate of 5-fluorouracil and cyclophosphamide in natural surface waters, Environmental Science & Technology, Vol. 47, 2013, 4104-4112.

Llewellyn N., Lloyd P., Jurgens M.D., Johnson A.C., Determination of cyclophosphamide and ifosfamide in sewage effluent by stable isotope-dilution liquid chromatography-tandem mass spectrometry, Journal of Chromatography A, Vol. 1218, 2011, 8519-8528.

Moldovan Z., Occurrences of pharmaceutical and personal care products as micropollutants in rivers from Romania, Vol. 64, Chemosphere 2006, 1808-1817.

Rabii F.W., Segura P.A., Fayad P.B., Sauve S., Determination of six chemotherapeutic agents in municipal wastewater using online solid-phase extraction coupled to liquid chromatography- -tandem mass spectrometry, Science of the Total Environment, No. 1, 2014, 792-800.

Steger-Hartmann T., Kummerer K., Hartmann A., Biological degradation of cyclophosphamide and its occur

Steger-Hartmann T., Kummerer K., Trace analysis of the antineoplastics ifosfamide and cyclophosphamide in sewage water by two-step solid-phase extraction and gas chromatography- -mass spectrometry, Journal of Chromatography A, Vol. 726, 1996, 179-184.

Świetlik J., Nawrocki J., Farmaceutyki w środowisku wodnym – występowanie, znaczenie i usuwanie, Zaopatrzenie w wodę, jakość i ochrona wód, Tom I, XIX Krajowa Konferencja, VII Międzynarodowa Konferencja, Poznań‒Zakopane 2006.

Valcarcel Y., Gonzalez A., Rodriguez-Gil J.L., Gil A., Catala M., Detection of pharmaceutically active compounds in the rivers and tap water of the Madrid Region (Spain) and potential ecotoxicological risk, Chemosphere, Vol. 84, 2011, 1336-1348.

Informacje

Informacje: Czasopismo Techniczne, 2014, Środowisko Zeszyt 1-Ś (20) 2014, s. 11 - 18

Typ artykułu: Oryginalny artykuł naukowy

Tytuły:

Polski:

Occurrence of anti-cancer drugs in the aquatic environment and efficiency of their removal ‒ the selected issues

Angielski:

Occurrence of anti-cancer drugs in the aquatic environment and efficiency of their removal ‒ the selected issues

Autorzy

Institute of Water Supply and Environmental Protection, Faculty of Environmental Engineering, Cracow University of Technology

Institute of Water Supply and Environmental Protection, Faculty of Environmental Engineering, Cracow University of Technology

Publikacja: 11.02.2015

Status artykułu: Otwarte __T_UNLOCK

Licencja: Żadna

Udział procentowy autorów:

Wojciech Balcerzak (Autor) - 50%
Piotr Rezka (Autor) - 50%

Korekty artykułu:

-

Języki publikacji:

Angielski