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Rat spleen in the course of Babesia microti invasion: histological and submicroscopic studies

Publication date: 24.11.2017

Acta Protozoologica, 2017, Volume 56, Issue 2, pp. 129 - 137

https://doi.org/10.4467/16890027AP.17.011.7486

Authors

,
Hubert Okła
Institute of Materials Science, Faculty of Computer Science and Materials Science, University of Silesia in Katowice, Poland
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,
Krzysztof Piotr Jasik
Department of Skin Structural Studies, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice
All publications →
,
Beata Rozwadowska
Provincial Sanitary and Epidemiological Station in Katowice, Poland
All publications →
,
Jan Słodki
Department of Skin Structural Studies, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice
All publications →
,
Danuta Urbańska-Jasik
Department of Animal Histology and Embryology, Faculty of Biology and Environmental Protection, University of Silesia in Katowice, Poland
All publications →
,
Michał Grelowski
August Chełkowski Institute of Physics, Faculty of Mathematics, Physics and Chemistry, University of Silesia in Katowice, Poland
All publications →
,
Ewa Chmielik
Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland
All publications →
,
Aleksandra Słodki
Department of Skin Structural Studies, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Poland
All publications →
,
Marta Albertyńska
Department of Skin Structural Studies, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Poland
All publications →
Aniela Grajoszek
Department for Experimental Medicine, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland
All publications →

Titles

Rat spleen in the course of Babesia microti invasion: histological and submicroscopic studies

Abstract

The course of babesiosis in humans is characterized by various intensity levels − from a subclinical level to the severe one − associated with multiple organ failure, which leads to death. The aim of this study was to evaluate the effect of 21-day and 6-month invasion of B. microti on Wistar rats spleen. Histological changes in the rats’ spleen were characterized by swelling of splenic tissue, especially the tissue adjacent to the capsule. In the structure of the white pulp in some rats, high concentrations of lymphocytes occurred. The boundary between the white pulp and red pulp was blurred. In the red pulp structure of rats, a lot of macrophages and extracellular deposits of bilirubin were present. The submicroscopic studies showed that the nuclear matrix was slightly shrunken. In the red pulp fragments of the damaged cells were located in the intercellular spaces. Near these areas, many thrombocytes were visible. The ultrastructural observation also revealed thickened endoplasmic reticulum membranes, local cellular swelling filled with amorphous substance, and digested erythrocytes. B. microti invasion affects the splenic morphology and ultrastructure in rats. The immunological hyperactivity and signs of inflammation indicate an important role of spleen in a fight against parasites. 

References

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Information

Information: Acta Protozoologica, 2017, Volume 56, Issue 2, pp. 129 - 137

Article type: Original article

Authors

Institute of Materials Science, Faculty of Computer Science and Materials Science, University of Silesia in Katowice, Poland

Department of Skin Structural Studies, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice

Provincial Sanitary and Epidemiological Station in Katowice, Poland

Department of Skin Structural Studies, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice

Department of Animal Histology and Embryology, Faculty of Biology and Environmental Protection, University of Silesia in Katowice, Poland

August Chełkowski Institute of Physics, Faculty of Mathematics, Physics and Chemistry, University of Silesia in Katowice, Poland

Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Poland

Department of Skin Structural Studies, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Poland

Department of Skin Structural Studies, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia in Katowice, Poland

Department for Experimental Medicine, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland

Published at: 24.11.2017

Article status: Open

Licence: CC BY-NC-ND  licence icon

Percentage share of authors:

Hubert Okła (Author) - 10%
Krzysztof Piotr Jasik (Author) - 10%
Beata Rozwadowska (Author) - 10%
Jan Słodki (Author) - 10%
Danuta Urbańska-Jasik (Author) - 10%
Michał Grelowski (Author) - 10%
Ewa Chmielik (Author) - 10%
Aleksandra Słodki (Author) - 10%
Marta Albertyńska (Author) - 10%
Aniela Grajoszek (Author) - 10%

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English