TY - JOUR
TI - Actinomycin D as an Epimutagen in Protists
AU - Uspenskaya, Zoya I.
AU - Yudin, Alexander L.
TI - Actinomycin D as an Epimutagen in Protists
AB - 
A previously unrecorded property of actinomycin D, a well-known antibiotic, was discovered in the course of long-term genetic research on the amoeba Amoeba proteus and the ciliate Dileptus anser. In these protists actinomycin D can induce an unusual type of hereditary variation, which we refer to as the inheritable destabilization of characters. A number of features indicate that this variation is epigenetic, that is, not caused by mutations in the DNA. Therefore, actinomycin D may be considered as an inducer of epigenetic inheritable changes, in other words, as an epimutagen.

VL - 2017
IS - Volume 56, Issue 3
PY - 2017
SN - 0065-1583
C1 - 1689-0027
SP - 139
EP - 147
DO - 10.4467/16890027AP.17.012.7493
UR - https://ejournals.eu/en/journal/acta-protozoologica/article/actinomycin-d-as-an-epimutagen-in-protists
KW - actinomycin D
KW - Amoeba proteus
KW - Dileptus anser
KW - epigenetic variation
KW - epimutagen
KW - inheritable destabilization of characters