@article{f2edfd68-867c-4899-af85-6da8ec602074,
author = {Zoya I.  Uspenskaya, Alexander L. Yudin},
title = {Actinomycin D as an Epimutagen in Protists},
journal = {Acta Protozoologica},
volume = {2017},
number = {Volume 56, Issue 3},
year = {2017},
issn = {0065-1583},
pages = {139-147},keywords = {actinomycin D; Amoeba proteus; Dileptus anser; epigenetic variation; epimutagen; inheritable destabilization of characters},
abstract = {A previously unrecorded property of actinomycin D, a well-known antibiotic, was discovered in the course of long-term genetic research on the amoeba Amoeba proteus and the ciliate Dileptus anser. In these protists actinomycin D can induce an unusual type of hereditary variation, which we refer to as the inheritable destabilization of characters. A number of features indicate that this variation is epigenetic, that is, not caused by mutations in the DNA. Therefore, actinomycin D may be considered as an inducer of epigenetic inheritable changes, in other words, as an epimutagen.},
doi = {10.4467/16890027AP.17.012.7493},
url = {https://ejournals.eu/en/journal/acta-protozoologica/article/actinomycin-d-as-an-epimutagen-in-protists}
}