TY - JOUR
TI - Analysis of short tandem repeat mutations in paternity cases from Masovian Voivodeship provinces form years 2018-2022 based on materials of the Department of Forensic Medicine, Medical University of Warsaw
AU - Żak, Krzysztof
AU - Konarzewska, Magdalena
TI - Analysis of short tandem repeat mutations in paternity cases from Masovian Voivodeship provinces form years 2018-2022 based on materials of the Department of Forensic Medicine, Medical University of Warsaw
AB - In paternity cases, genetic tests are of great importance as they allow to exclude or confirm paternity. As a result of paternity tests we can also obtain information on the frequency of short tandem repeat mutations, which are important in the statistical analysis of test results. A total of 468 cases of full paternity trios (mother, child and alleged father) were analysed from years 2018 - 2022 from the central part of Poland. For further analysis of the occurrence of the mutation 346 cases in which paternity was confirmed were qualified. DNA analysis was performed using the PowerPlex®Fusion 6C kit (Promega, USA). 36 mutations were observed in 13 of the 23 genetic markers analysed. 94.44% were one-step mutations and 5.56% were two-step mutations. Among those mutations, there were 18 insertions and 10 deletions, while in 8 cases it was not possible to determine whether an insertion or deletion occurred. There was also a significantly higher share of the father mutation in relation to the mother mutation at a ratio of 4.17:1.
VL - 2023
IS - Vol. 73 (2)
PY - 2023
SN - 0324-8267
C1 - 1689-1716
SP - 139
EP - 148
DO - 10.4467/16891716AMSIK.23.012.18687
UR - https://ejournals.eu/en/journal/amsik/article/analysis-of-short-tandem-repeat-mutations-in-paternity-cases-from-masovian-voivodeship-provinces-form-years-2018-2022-based-on-materials-of-the-department-of-forensic-medicine-medical-university-of-warsaw-analiza-mutacji-krotkich-powtorzen-tandemowych-w-s
KW - paternity testing
KW - mutation rates
KW - STR loci
KW - PowerPlex®Fusion 6C