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Problems of Forensic Sciences

The detection and determination of new LSD derivatives in biological material using the LC-MS/MS technique

Data publikacji: 23.06.2022

Problems of Forensic Sciences (Z Zagadnień Nauk Sądowych), 2021, 128, s. 227 - 240

https://doi.org/10.4467/12307483PFS.21.013.15883

Autorzy

,
Piotr Adamowicz
Instytut Ekspertyz Sądowych im. Prof. dra Jana Sehna w Krakowie, Kraków
https://orcid.org/0000-0002-7830-9329 Orcid
Wszystkie publikacje autora →
Karolina Mulka
Uniwersytet Śląski w Katowicach, Bankowa 12, 40-007 Katowice
Wszystkie publikacje autora →

Abstrakt

Psychedelics derived from lysergic acid diethylamide (LSD) represent one of the groups of new psychoactive substances (NPS) that have been gaining popularity in recent years. Due to their very high potency, they are taken in small doses and their identification in biological material is problematic. The compounds from this group, which appear in low concentrations in biological material and metabolise rapidly, require sensitive and selective analytical methods if they are to be detected. A method for the detection and determination of LSD and its new derivatives (ALD-52, 1P-LSD, 1cP-LSD, and 1B-LSD) in whole blood using the LC-MS/MS technique was therefore developed and validated. The analytes were isolated from the blood (0.2 mL) by liquid-liquid extraction with ethyl acetate and acetate buffer (pH 5.5). The method developed was linear in the range of 0.5−10 ng/mL. The limit of detection (LOD) was 0.01 ng/mL for each analyte and the lowest point on the calibration curve was taken as the limit of quantification (LOQ). The method developed is sensitive and samples can be prepared for analysis quickly and easily. The procedure can be applied widely in the analysis of LSD derivatives in biological material –for forensic or clinical purposes, for example –and can easily be expanded for use with further LSD derivatives.

Bibliografia

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Informacje

Informacje: Problems of Forensic Sciences (Z Zagadnień Nauk Sądowych), 2021, s. 227 - 240

Typ artykułu: Oryginalny artykuł naukowy

Tytuły:

Angielski:
The detection and determination of new LSD derivatives in biological material using the LC-MS/MS technique

Autorzy

https://orcid.org/0000-0002-7830-9329

Piotr Adamowicz
Instytut Ekspertyz Sądowych im. Prof. dra Jana Sehna w Krakowie, Kraków
https://orcid.org/0000-0002-7830-9329 Orcid
Wszystkie publikacje autora →

Instytut Ekspertyz Sądowych im. Prof. dra Jana Sehna w Krakowie, Kraków

Uniwersytet Śląski w Katowicach, Bankowa 12, 40-007 Katowice

Publikacja: 23.06.2022

Otrzymano: 25.11.2021

Zaakceptowano: 09.03.2022

Status artykułu: Otwarte __T_UNLOCK

Licencja: CC BY-NC-ND  ikona licencji

Udział procentowy autorów:

Piotr Adamowicz (Autor) - 50%
Karolina Mulka (Autor) - 50%

Korekty artykułu:

-

Języki publikacji:

Angielski, Polski

Liczba wyświetleń: 359

Liczba pobrań: 518