%0 Journal Article
%T Biomechanical aspects of atherosclerosis
%A Wasilewski, Jarosław
%A Mirota, Kryspin
%J Czasopismo Techniczne
%V 2013
%R 10.4467/2353737XCT.14.042.2625
%N Chemia Zeszyt 1-Ch (1) 2013
%P 89-98
%K atherosclerosis pathogenesis, shear stress, computational fluid dynamics
%@ 0011-4561
%D 2014
%U https://ejournals.eu/czasopismo/czasopismo-techniczne/artykul/biomechanical-aspects-of-atherosclerosis
%X 
	Pathogenesis of atherosclerosis is a complex multifactorial process of vascular wall injury. It is widely accepted that the local hemodynamic factors, in particular, disturbed flow and low/ oscillatory shear stress leads to the plaque development. We present a consistent concept of atherosclerosis aetiology, taking into consideration the four main components contributing in the atheroma formation: geometric, hemodynamic, hemorheological, and mechanical risk factors. Exemplary illustrative flow simulation results for formulated concept have been presented. It assumes the pulsatile non-Newtonian fluid flow and uses realistic coronary artery geometry based on medical imaging and segmentation.